Diabetes Impaired Ischemia-Induced PDGF (Platelet-Derived Growth Factor) Signaling Actions and Vessel Formation Through the Activation of Scr Homology 2-Containing Phosphatase-1

CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1.

CD300F is known to exhibit inhibitory activity in myeloid cells through its intracellular ITIM. To investigate the effect of CD300F stimulation on TLR signaling, the human acute monocytic leukemia cell line THP-1 was treated with CD300F-specific mAbs or two synthetic peptides that represented the ITIM-like domains of CD300F. Treatment with these agents blocked TLR2-, 3-, 4-, and 9-mediated expr...

Platelet - derived growth factor ( PDGF ) - AB - mediated phosphorylation of PDGF , 1 receptors Steven

Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin, and stimulates the proliferation of density-arrested Balb/c-3T3 fibroblasts (Pledger et al., 1978; Williams et al., 1982; Sturani et al., 1989; Coats et al., 1991). PDGF was first purified from human platelets and shown to consist of a heterodimer composed of two disulphide-linked polypeptide chains, desi...

Containing Phosphatase 1 Activation of Src Homology Region 2 TRIF - Mediated TLR Signaling through CD 300 F Blocks Both

Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling.

Growth hormone (GH) signaling requires activation of the GH receptor (GHR)-associated tyrosine kinase, JAK2. JAK2 activation by GH is believed to facilitate initiation of various pathways including the Ras, mitogen-activated protein kinase, STAT, insulin receptor substrate (IRS), and phosphatidylinositol 3-kinase systems. In the present study, we explore the biochemical and functional involveme...

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration.

LPPs (lipid phosphate phosphatases) are members of a family of enzymes that catalyse the dephosphorylation of lipid phosphates. The only known form of regulation of this family of enzymes is via de novo expression of LPP isoforms in response to growth factors. In this respect, we evaluated the effect of moderate increases in the expression of recombinant LPP1 on signal transduction by both G-pr...